• Two Easy Ways to Start Earning Rewards!

    rewards header
    Become a member today!
    Members-only pricing and offers, personalized care notifications, Vital Care points back on every purchase and more!
    Already a member? Sign in
    Petco Pay LogoBecome a credit card member today!

    Earn 2X Pals Rewards points at Petco
    when you use Petco Pay!

    APPLY NOW
    Learn More About Petco Pay Benefits

Simparica Trio Prescription Flea & Tick Medicine

1 - 6 of 6 results
Down arrow icon

    Pet owners can efficiently guard their furry friends against pests with Simparica Trio Prescription Flea & Tick Medicine products. Provide lasting defense for your pets from common parasites while ensuring optimal health and comfort.

    • All-in-one protection: Simparica Trio offers comprehensive coverage against fleas, ticks, heartworm, roundworms, and hookworms
    • Convenient dosing: A single monthly chewable tablet makes administering Simparica Trio hassle-free
    • Fast-acting formula: Sarolaner, moxidectin, and pyrantel work together to eliminate existing infestations and prevent new ones
    • Preferred by professionals: Simparica Trio's unique combination gives veterinarians a reliable option for parasite control
    • Bypass traditional spot-ons: Choose the once-monthly oral treatment that doesn't require isolating your pet during application

    Invest in Simparica Trio Prescription Flea & Tick Medicine products to grant your beloved pets the all-encompassing defense they need against various harmful parasites, keeping them protected and content throughout the year.

    FAQs About Simparica Trio

    Simparica Trio is a once-monthly chewable tablet that can treat existing flea and tick infestations and help prevent fleas, ticks, heartworm, roundworm and hookworm. It contains sarolaner, which kills fleas and ticks, moxidectin, which helps prevent heartworm disease and pyrantel, which treats and controls roundworm and hookworm.

    Simparica Trio has been approved for dogs as young as 8 weeks and weighing as little as 2.8 lbs. However, it hasn’t been evaluated in pregnant and lactating dogs. It should also be used with caution in dogs who have seizures because the ingredient sarolaner has been associated with seizures, ataxia and tremors.

    Most dogs won’t experience side effects. However, the most common were vomiting and diarrhea. In addition, before prescribing Simparica Trio, your veterinarian will perform a test to ensure your pup is heartworm negative because giving heartworm medicine to a dog that is already infected can be fatal. Consult your veterinarian if you think your dog is experiencing side effects and for general advice.

    Yes—heartworm medicine for dogs is essential for all sizes, ages and lifestyles. Heartworm is transmitted through mosquito bites, and some pet parents think if their pup lives an indoor or city life, they don’t need to worry about heartworm. But it’s always better to be safe than sorry. Heartworm can be a devastating disease that leaves permanent damage on the lungs and heart and frequently results in death. And the cost of treating heartworm is far higher than preventing it in the first place.

    IMPORTANT SAFETY INFORMATION: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.

      Styled arrow button